How to Mend a Broken Heart?

How can you mend a broken heart?.

Metabolic modulation: a means to mend a broken heart.

Heart failure is a clinical syndrome characterized by progressive deterioration of heart pump function that is very common in our society.1 It is a highly lethal disease with an annual mortality rate ranging from 5% to 10% in those with mild symptoms to 30% to 40% in those with severe symptoms.1 The morbidity associated with heart failure is also substantial such that heart failure is currently...

How to mend a broken heart: a major stab wound of the left ventricle

A 28-year-old male admitted with a stab wound under his left nipple, underwent emergency surgery because of confusion, a decreasing blood pressure and increasing tachycardia. A median sternotomy incision was made and after establishing cardiopulmonary bypass, a 7 cm wound in the left ventricle and a smaller wound in the left atrium were repaired. An injured segment of lung was resected and the ...

Choosing wisely - when to mend a broken heart with ECMO?

Refractory cardiac shock in the cardiac surgical intensive care unit confers significant morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) has become a common intervention for refractory cardiogenic shock when other therapies have failed. However, it is difficult to predict who will benefit from this costly, resource-intensive, but potentially life-saving technology. Here, we ...

Myocyte transplantation for myocardial repair: a few good cells can mend a broken heart.

Cell transplantation is a potential therapeutic approach for patients with chronic myocardial failure. Experimental transplantation of neonatal and fetal cardiac myocytes showed that the grafted cells can functionally integrate with and augment the function of the recipient heart. Clinical application of this approach will be limited by shortage of donors, chronic rejection, and because it is e...